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Requirement and role of arachidonic acid in the differentiation of pre-adipose cells

Science Advances , 6 (31), eaba6505

We also studied the consequences of PA treatment on the expression of other well-known ferroptosis-related genes and found that PA induced a decreased expression of two key anti-ferroptotic genes: the gluthatione peroxidase 4 (GPX4) and the ferroptosis suppressor protein 1 (FSP1) and an enhanced expression of two key pro-ferroptotic genes: the arachidonate 15-lipoxygenase (ALOX15) and the acyl-CoA synthetase long chain family member 4 (ACSL4)

The isoelectric point of a nucleotide is identified as a specific pH value where the amount of positive and negative charges within the nucleotide equate, yielding a net charge of zero. Phosphate groups constitute a crucial component of nucleotides

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